The Stanford Blood Center

3373 Hillview Ave

Palo Alto, Santa Clara County 94304

USA

THE MICHAELANGELO LAB

 

THE MIBI TEAM

 

Mike Angelo, MD PhD

Principal Investigator

B.S. University of Mississippi

MD Ph.D. Duke University

Residency in Clinical Pathology, UCSF

Mike's academic background spans across the fields of physics, biochemistry, electrical engineering, and medicine. During his residency  he became interested in developing novel methods for immunohistochemical multiplexing using mass spectrometry leading to the development of MIBI during his postdoctoral work in the Nolan lab at Stanford University. Mike is now interested in optimizing MIBI and other mass reporter-based technologies further with the goal of identifying new transcriptional and translational signatures in solid tissue malignancies, and in allergic and other immunological disorders, that can be used to improve clinical diagnosis and treatment

Marc Bosse, PhD

Senior Staff Scientist

B.Sc. Microbiology, University of Montreal

M.Sc. Microbiology & Immunology, University of Montreal

Ph.D. in Experimental Medicine, Laval University, Canada

Postdoctoral fellow, Robarts Research Institute

Postdoctoral Fellow, SCC-RI, McMaster University

Research Area: Instrumentation and assay development

mbosse(at)stanford.edu

Marc has broad experience in microbiology, human stem cell biology and asthma research. He also worked in translational research developing a production process for an advance cell therapy product. He now works closely with Drs. Angelo and Bendall on improving MIBI technology. He is responsible for the maintenance of the MIBI-TOF imager and its day-to-day operation. He is also engaged in the development and adaption of molecular techniques for MIBI.

Leeat Keren, PhD

Postdoctoral Fellow, Damon Runyon Fellowship

B.Sc. Bioinformatics, Tel-Aviv University 

M.Sc. Computational Biology, Weizmann Institute

Ph.D. Computational Biology, Wiezmann Institute

Research Area: Computational Tool Development and Tumor-Immune Interactions 

lkeren(at)stanford.edu

The immune system plays a critical role in modulating cancer progression. However, knowledge of the composition, phenotype, organization, and interactions between immune cells and tumor cells is limited. Leeat applies multiplexed imaging to study the interplay between the tumor and the immune system. She develops computational tools that allow to tease various layers of information from rich multiplexed-imaging data and employ them to infer design principles in tumor-immune interactions.

Shirley Greenbaum, MD

Postdoctoral Fellow

MD, The Hebrew University of Jerusalem, Hadassah Medical School

Research Area: Placenta Immunobiology

gshirley(at)stanford.edu

After completing her MD at the Hebrew University, Israel, Shirley joined the OBGYN residency program at Soroka University Hospital, of which she completed 2.5 years. Shirley then became very interested in research, particularly pregnancy complications related to the placenta and decided to take a time-off from clinical work to study the immunological interface between the mother and fetus.

Tyler Risom, PhD

Postdoctoral Fellow

B.A. Molecular, Cellular Developmental Biology, University of Colorado

Ph.D. Cancer Biology, Oregon Health & Science University

Research Area: Ductal Cell Carcinoma In Situ

trisom(at)stanford.edu

Tyler uses multiplexed imaging to profile the phenotypic content, phenotypic identity, and paracrine signaling between tumor and stromal cells in patient samples of ductal carcinoma in situ (DCIS) that did, or did not, recur with invasive breast carcinoma. This work will hopefully lead to the identification of biomarkers that can better risk stratify DCIS patients as well as identifying new molecular targets that could inhibit the progression of breast cancer to an invasive state.

Erin McCaffrey

Graduate Student, Immunology, NSF Fellowship

B.S. Microbiology, University of Maryland-College Park

Research Area: Tuberculosis and Granulomatous Diseases

erinmcc(at)stanford.edu

During her undergraduate work in microbiology Erin became interested in the complex immune-evasion strategies of M. tuberculosis (TB) and its massive global burden in underserved patient populations. Her work focuses on elucidating immune mechanisms within TB granulomas that may drive disparate clinical outcomes. She is employing MIBI to identify immune cell populations, define their phenotypes, and asses their histologic organization within granulomas across the disease spectrum of TB in both human and non-human primate models of infection.

Noah Greenwald

Graduate Student, Cancer Biology, Stanford Graduate Fellowship, Co-Advisor: Dr. Christina Curtis

B.A. Biophysics, Harvard University

Research Area: Computational Image Analysis and Cancer Biology

nfgreen(at)stanford.edu

Noah received his BA in Biophysics from Harvard University. He then worked for two years at Harvard Medical School and the Broad Institute in the labs of Drs. Rameen Beroukhim and Ian Dunn studying the genomics of brain tumors. Noah is interested in combining multiplexed imaging techniques with genomics to understand the tumor microenvironment and response to therapy. He also works on developing tools for cell segmentation and computational analysis.

Roshan Angoshtari, PhD

Alex Baranski

Staff Scientist

Ph.D. Genetics, Michigan State University

Research Area: Food Allergy

r.angoshtari(at)stanford.edu

Computational Staff

B.S. Mathematics, University of Chicago

Research Area: Machine learning and Computational Analysis

Alex is interested in the theoretical study and practical development of artificial intelligence, and looks to biological systems such as the immune system as a source of inspiration for how to construct computational models that can adapt and self-organize. He works primarily on building machine learning tools for data analysis, and applying dynamical systems, information, and automata theory to building numerical simulations.

Selena Ferrian, PhD

Senior Staff Scientist

B.Sc. Animal Science, Universitá di Bologna

M.Sc. Animal Sciences, Universitat Politècnica de Valencia

Ph.D. Health Sciences, Universidad CEU Cardenal Herrera/Aarhus University

Postdoctoral Fellow, TB/HIV Immunology, University of Cape Town

Research Area: TAMs in Glioblastoma

sferrian(at)stanford.edu

Prior to Stanford Selena worked as a Research Scientist within the Immunotherapy Platform, led by Nobel laureate Professor James Allison at MD Anderson Cancer Center, where she analyzed and interpreted data for immunotherapy clinical trials and implemented an imaging technology to study the immune landscape in metastatic renal cell carcinoma.As a Sr. Scientist at Stanford University, Selena is interested in investigating the role of glioma infiltrating macrophages in disease pathogenesis. More specifically, she wants to understand how cell-cell communication affects macrophage cell types and states in Glioblastoma in order to accelerate future immunotherapy strategies. Concomitantly Selena is overseeing and supporting Dr. Angelo’s research collaborations derived from the implementation of the MIBI technology in diseased tissue.

Alea Delmastro

Undergraduate Researcher, Stanford University

B.S. Chemical Engineering (Class of 2020)

Research Area: Tuberculosis and Granulomatous Diseases

alead(at)stanford.edu

Alea is an undergraduate student in the Chemical Engineering department. She is interested in studying infectious disease, specifically relating to Tuberculosis (TB) infection. Despite its large global burden, the human immune response to Mycobacterium tuberculosis remains poorly characterized. Utilizing multiplexed ion beam imaging and computational methods for single cell analyses, Alea aims to elucidate the composition and structure of TB granulomas in the Non-Human Primate model of both latent and active infection.

 

LAB ALUMNI

 

DIANA MARQUEZ

Current Position: Research Associate, Spitzer Lab, UCSF

HARRIS FIENBERG, PHD

Current Position: CEO of Ionpath

JENNIFER WANG

Current Position: Medical Student at University of Southern California